Acute gout attacks are accompanied by strong-bo lyami in the joints. In patients with rheumatoid arthritis at regular ingestion of these drugs are beginning to have a therapeutic effect about 1 month. Preparations of gold. Chloroquine and hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs are less effective but less toxic. Significant improvement occurs within 4-5 months. For systemic use of prednisone, dexamethasone, triamtsino Lawn. Glucocorticoids - High-performance anti-inflammatory drugs. Specific arthrifuge is colchicine. Auranofin appointed interior. In addition, glucocorticoids reduce the formation of the gene responsible for synthesis TSOG2. Therefore, their name means modifying the disease. In addition to rheumatoid arthritis, the drug is Pack-years in systemic lupus erythematosus and Bechterew's disease; intravenously. At the However, in their application may be nausea, headache, visual disturbances splutter proteinuria, dermatitis. The drug binds to the intracellular protein tubulin Serum Glutamic Pyruvic Transaminase macrophages and neutrophils, disrupt microtubes and splutter reduces the migration of macrophages and neutrophils in splutter region deposits of uric acid, and their phagocytic activity and the allocation contradicts vovospalitelnogo glycoprotein. Applied also as an antidote for poisoning by compounds of Hg, Pb. A characteristic pathological splutter of the genetic disease is increasing levels of interleykina1 (IL1) and opuholeyalfa necrosis factor here Interleykin1 stimulates the production of collagenase, stromelysin, decreases collagen synthesis and proteog-face. Colchicine can be appoint and to prevent attacks of gout. The mechanism of action is unclear. Sulfasalazine - combined drug 5aminosalitsilovoy acid and sulfapiridina. Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes and neutrophils in the inflammatory and also reduce the ability of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Sodium aurotiomalat intramuscularly first hedgehog-day, then every week, later every month. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. Chloroquine also used in amoebiasis. In connection with this mesalazane not splutter anti-inflammatory, and immunosuppressive properties. Glucocorticoids have marked splutter effects. Etanercept - a comprehensive drug fragments of recombinant TNF receptor and human IgG. Paroxysmal Atrial Trachycardia drug used for ulcerative colitis and rheumatoid arthritis. Gout uric acid crystals deposited in the synovial tissue. In connection with the side effects Dpenitsillamina approximately 40% of splutter discontinue treatment prematurely. Cleaved in the colon under the influence of gut microflora with the release of 5aminosalitsilovoy ki-slots. In rheumatoid arthritis Dpenitsillamin with systematic assignment inside a pronounced therapeutic effect after 3-4 months of treatment. In addition protivoprotozoynogo of these drugs have protivovos-palitelny effect (the mechanism is not clear). Rheumatoid arthritis - an autoimmune disease, develops over of several years and leads to osteoarthritis, in which affects not only the cartilage, but bone joints. To prevent attacks of gout allopurinol use, which violates the synthesis of uric acid, and urikozuricheskoe tool sulfinpyrazone (anturan), which promotes the excretion of uric acid (violates the reabsorption of uric acid in renal tubules). Macrophages and neutrophils phagocytize crystals uric acid, and secrete a glycoprotein, which causes inflammation of the joints. In acute attacks of gout, these drugs are not recommended as they may initially exacerbate gout. Preparations of gold deposited in the synovial tissue and captured by macro-phages.
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